Watch the Entire 2018 Einstein-Montefiore Presidential Lecture Featuring Drs. Betsy Herold and William Jacobs

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Watch the Entire 2018 Einstein-Montefiore Presidential Lecture Featuring Drs. Betsy Herold and William Jacobs

The second annual Einstein-Montefiore Presidential Lecture featured lectures by Betsy C. Herold, M.D., and William R. Jacobs, Jr., Ph.D. on their collaborative efforts to develop a vaccine for herpes viruses HSV-1 and HSV-2. The novel vaccine they've engineered has shown remarkable results in early testing and plans are now under way to assess the vaccine in Phase 1 clinical trials.

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Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence

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Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence

In February the Proceedings of the National Academy of Sciences published a contribution article from the Jacobs lab describing two deletions encoding an enzyme of the respiratory chains in Mycobacterium tuberculosis profoundly effect the viability and virulence of the mycobacterium. Screening compound libraries against both genes will lead to promising drug candidates to fight tuberculosis.

Read the article here.

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Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice

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Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice

In a paper recently published in Antimicrobial Agents and Chemotherapy, Dr. Catherine Vilcheze discusses her experiments that demonstrate Vitamin C in combination with first-line TB drugs (isoniazid and rifampicin) will kill an M. tuberculosis infection in mice.

Read the paper here

On January 4th Steve Baragona from Voice of America interviewed Dr. Jacobs about these findings in an article you can read here.

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Major PublicationS from the Jacobs Lab in 2016!

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Major PublicationS from the Jacobs Lab in 2016!

January 19, 2016 in PNASSeparable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence

Describes the ESX-3 type VII secretion system's role in iron acquisition in M. tuberculosis

August 4, 2016 in JCI InsightHSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates

Describes the how vaccine vector HSV ΔgD completely protects against highly virulent clinical isolates of HSV-1 and HSV-2

September 26, 2016 in J. BacteriolFluorescent Reporter DS6A Mycobacteriophages Reveal Unique Variations in Infectibility and Phage Production in Mycobacteria

Describes the DS6A reporter phage that uniquely plaques to M. tuberculosis. This is the PhD Thesis paper for Dr. Oren Meyer!

October 25, 2016 in mBioDual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

Describes the development of dual-reporter mycobacteriophages that cause a culture of M. tuberculosis to glow green inititally and glow red when entering a persister state. 

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